Travelers in search of wide-open spaces and solitude will find both in abundance in Patagonia, which stretches over Chile and Argentina. The enormous expanse of wild South American land is home to windswept steppes, dramatic mountains, glacial lakes, and one lonely road: the famous RN 40, which runs parallel to the Andes. Explore the Perito Moreno, Upsala, and Spegazzini glaciers by kayak; visit Torres del Paine, Los Glaciares, or Tierra del Fuego national parks; or trek on the Patagonian Ice Field. You can also ride the train to the end of the world in Tierra del Fuego, or take a sailing expedition on the Beagle Channel.