This imposing church is a repository of important Baroque art and architecture and the frescoed dome, designed by Carlo Maderno, is the second largest in Rome after St. Peter’s. Underneath this mighty cupola, the church features extravagant marble chapels and tombs of wealthy 16th-century Italian aristocrats, including the Strozzis, the Barberinis, and several popes. Great names like Michelangelo and Bernini had a hand in designing these sarcophagi. Because of its wealth of art and architecture, the basilica is best visited with a guide. Many tours of Rome’s most important basilicas and churches, as well as itineraries focusing on the city’s most important Catholic landmarks, include a stop here.